RECENT DEVELOPMENTS AND MULTIPLE BIOLOGICAL ACTIVITIES AVAILABLE WITH 1, 8- NAPHTHYRIDINE DERIVATIVE S: A REVIEW
By: Gurjar, Vinod Kumar
.
Contributor(s): Gurjar, Vinod Kumar.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(1).Description: 17-37p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Within the
wide
range of
nitrogen
-containing
heterocyclic
compounds,
the derivatives of 1,8
-naphthyridine (NPTR) have gained a rising interest
due to their reported versatile biological activities. The
derivatives of
NPTR
scaffold
are found to
invite
special
interest
from
researchers nowadays
on
the
significance
of their
manifes
tations of multiple
attractive
pharmacological activities which
establish
them
as
an effective and versatile tool
in
pharmaceutical
chemistry
and
drug discovery
. The
diverse biological
activities mainly include
anti
-inflammatory,
antimicrobial,
antiviral,
anticancer, antihypertensive and analgesic activities.
No
vel
NPTR scaffold
has
emerged
its
potency to treat
neurological dis
eases
like
depression
and
Alzheimer's
disease
. Further
these
agents
possess
different inhibitory activities
, such as anti
-HIV, anti
-
osteoporotic, α
v
β
3
antagonism,
antimalarial, platelet aggregation, anti
-oxidant,
anti
-allergic, gastric antisecretory, anticonvulsant,
epidermal growth factor receptor
(EGFR
)
inhibition, protein kinase inhibition, ionotropic propert
ies, β
3
Keyword
s
:
1,8
-Nap
hthyridine
(NPTR)
, Quinolone
, Antimicrobial
activity
, Anticancer
activity
, Antitumor
, Anti
-inflammatory
activity
, Antimalarial
antihypertensive,
Antiplatelet
activity
,
αvβ3 antagonist
antagonism,
phosphodiesterase
4 (PDE 4)
inhibitions
, adenosine receptor agonist
ic
activity
, adrenoceptors antagonism and
DNA stabilizing
activi
ty, etc
. In this review, we
highlight the
update
s of different 1,8
-naphthyridine
derivatives
and
explain
the key data available in the context of various biological activities of
NPTR
derivatives available from the literature. This
may direct
opportunity in
researches
in the synthesis of n
ovel
medicinal agents
and
the
development
of
new
heterocycles
for modification of
existing biological actions as well as evaluation of other possible pharmacological activities
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020933 |
Within the
wide
range of
nitrogen
-containing
heterocyclic
compounds,
the derivatives of 1,8
-naphthyridine (NPTR) have gained a rising interest
due to their reported versatile biological activities. The
derivatives of
NPTR
scaffold
are found to
invite
special
interest
from
researchers nowadays
on
the
significance
of their
manifes
tations of multiple
attractive
pharmacological activities which
establish
them
as
an effective and versatile tool
in
pharmaceutical
chemistry
and
drug discovery
. The
diverse biological
activities mainly include
anti
-inflammatory,
antimicrobial,
antiviral,
anticancer, antihypertensive and analgesic activities.
No
vel
NPTR scaffold
has
emerged
its
potency to treat
neurological dis
eases
like
depression
and
Alzheimer's
disease
. Further
these
agents
possess
different inhibitory activities
, such as anti
-HIV, anti
-
osteoporotic, α
v
β
3
antagonism,
antimalarial, platelet aggregation, anti
-oxidant,
anti
-allergic, gastric antisecretory, anticonvulsant,
epidermal growth factor receptor
(EGFR
)
inhibition, protein kinase inhibition, ionotropic propert
ies, β
3
Keyword
s
:
1,8
-Nap
hthyridine
(NPTR)
, Quinolone
, Antimicrobial
activity
, Anticancer
activity
, Antitumor
, Anti
-inflammatory
activity
, Antimalarial
antihypertensive,
Antiplatelet
activity
,
αvβ3 antagonist
antagonism,
phosphodiesterase
4 (PDE 4)
inhibitions
, adenosine receptor agonist
ic
activity
, adrenoceptors antagonism and
DNA stabilizing
activi
ty, etc
. In this review, we
highlight the
update
s of different 1,8
-naphthyridine
derivatives
and
explain
the key data available in the context of various biological activities of
NPTR
derivatives available from the literature. This
may direct
opportunity in
researches
in the synthesis of n
ovel
medicinal agents
and
the
development
of
new
heterocycles
for modification of
existing biological actions as well as evaluation of other possible pharmacological activities
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